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Drug Interactions With Dronedarone

Dronedarone Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when dronedarone is combined with any of the drugs listed above.
Beta Blockers
Combining dronedarone with a beta blocker may increase the risk of low heart rate. Also, dronedarone may increase the level of some beta blockers in the bloodstream, increasing the risk of beta blocker side effects.
Calcium Channel Blockers
Combining dronedarone with a calcium channel blocker may increase the level of both medications in the bloodstream (depending on the particular calcium channel blocker). It may also increase the risk of serious problems such as a slow heart rate (bradycardia) or irregular heart rhythm (arrhythmia).
You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine dronedarone with a calcium channel blocker.
Certain Diuretics
Some diuretics may cause low electrolytes (such as low potassium or magnesium levels). Combining such diuretics with dronedarone may increase the risk of low electrolytes (which may, in turn, increase the risk of dangerous arrhythmias due to dronedarone). If you take dronedarone with such diuretics, your electrolytes will need to be carefully monitored.
CYP 3A4 Inducers
The liver metabolizes (breaks down) dronedarone using an enzyme known as CYP 3A4. Some medications (known as CYP 3A4 inducers) increase the activity of this enzyme. Taking dronedarone with a CYP 3A4 inducer may drastically decrease the level of dronedarone in the blood, possibly making it much less effective. It is not recommended to take dronedarone with a CYP 3A4 inducer.
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Dronedarone Drug Information

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