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Donepezil Side Effects

Common Side Effects

Donepezil has been studied thoroughly in clinical trials. In these studies, side effects are always documented and compared to those that occur in a similar group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. 
Based on these studies, the most common side effects with donepezil were:
  • Nausea -- occurring in up to 19 percent of people
  • Diarrhea -- up to 15 percent
  • Insomnia -- up to 14 percent
  • Headache -- up to 10 percent
  • Generalized pain -- up to 9 percent
  • Dizziness -- up to 8 percent
  • Fatigue -- up to 8 percent
  • Vomiting -- up to 8 percent
  • Muscle cramps -- up to 8 percent. 


Other donepezil side effects occurring in more than 2 percent of the people included:
  • Loss of appetite
  • Skin discoloration
  • Decrease in weight
  • Depression
  • Abnormal dreams
  • Arthritis
  • Fainting
  • Tiredness
  • Frequent urination.

Rare Donepezil Side Effects

During clinical trials, there were also other side effects that occurred in less than 2 percent of people taking donepezil. For these side effects, it is difficult to tell whether they were actually caused by the medication or something else. These possible side effects include but are not limited to:
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Donepezil HCl

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