Dolasetron Dosing

To help prevent nausea and vomiting that may occur with surgery, the recommended dosage of dolasetron is 100 mg, taken within two hours before surgery. Dosing for children ages 2 to 16 is based on the child's weight -- 1.2 mg per kg of body weight. For the prevention of nausea and vomiting due to chemotherapy, the recommended dolasetron dosage is 100 mg taken two hours before chemotherapy.

 

Dolasetron Dosage: An Introduction

The dose of dolasetron mesylate (Anzemet®) that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • Your age and weight
  • Whether you are having surgery or chemotherapy
  • Other medications you may be taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dolasetron dose unless your healthcare provider specifically instructs you to do so.
 

Dolasetron Dosing for Surgery

For adults, the recommended dolasetron dose for the prevention of nausea and vomiting due to surgery is 100 mg taken by mouth within two hours before surgery. For children ages 2 to 16, the recommended dose is based on weight -- dolasetron 1.2 mg per kg of body weight (about 0.54 mg per pound) taken by mouth within two hours before surgery.
 
An injectable form of dolasetron is also available to be given during surgery for preventing nausea and vomiting (or to treat nausea and vomiting once it starts).
 

Dolasetron Dosing for Chemotherapy

For adults, the recommended dolasetron dose for the prevention of nausea and vomiting due to chemotherapy is 100 mg taken by mouth within one hour before chemotherapy. For children ages 2 to 16, the recommended dose is based on weight -- dolasetron 1.8 mg per kg of body weight (about 0.8 mg per pound) taken by mouth within one hour before chemotherapy.
 
An injectable form of dolasetron is also available to be given by IV about 30 minutes before chemotherapy.
 
(Dolasetron Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;