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Dinoprostone Side Effects

You may need immediate medical treatment if you are receiving dinoprostone and develop abnormally strong or frequent uterine contractions, severe uterine pain, or persistent vomiting. Fortunately, women generally tolerate this medicine well and most dinoprostone side effects tend to be minor. Some of the more commonly reported problems with this drug include diarrhea, fever, and vomiting.

An Introduction to Dinoprostone Side Effects

Just like any medicine, dinoprostone (Cervidil®, Prepidil®, Prostin E2®) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most women tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with dinoprostone. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Dinoprostone

Some dinoprostone side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Low blood pressure, which could cause dizziness or fainting
  • Abnormally strong or frequent uterine contractions
  • Severe uterine pain (lower abdominal pain or pelvic pain)
  • Abnormal, excessive, or persistent vaginal bleeding
  • Persistent fever, nausea, vomiting, abdominal (stomach) pain, or diarrhea
  • Chest pain or pressure
  • An abnormally beating heart or a feeling of fluttering in your chest
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing or swallowing.
Pregnancy and Pain

Dinoprostone Drug Information

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