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Dinoprostone Side Effects

Common Side Effects

Dinoprostone has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of women who received the drug were documented and compared to those that occurred in a similar group of women who either did not receive treatment or who were given a similar product that did not contain any active ingredients (a placebo).
Actual side effects may vary depending on the particular dinoprostone product. However, based on clinical studies, the most commonly reported side effects of any dinoprostone use included but were not limited to:
  • Vomiting -- in up to 67 percent of women
  • Fever -- up to 50 percent
  • Diarrhea -- up to 40 percent
  • Nausea -- up to 33 percent
  • Headache -- up to 10 percent
  • Shivering and chills -- up to 10 percent
  • Very strong or frequent uterine contractions -- in up to 6.6 percent
  • Fetal distress (signs that the fetus is not well, such as an abnormal heartbeat) -- up to 17 percent
  • Back pain -- up to 3.1 percent
  • Warm feeling in the vagina -- up to 1.5 percent.
Other reported dinoprostone side effects included but were not limited to:
  • Abdominal (stomach) pain
  • Joint swelling, aches, or pain
  • Flushing (a sudden warmth and redness of the face, neck, and chest)
  • Dizziness and fainting
  • Muscle aches, cramps, or pain
  • Vaginal pain
  • Shortness of breath
  • Endometriosis (when cells from the lining of the womb grow in other areas of the body)
  • Vaginal inflammation or infection
  • Weakness
  • Nighttime leg cramps
  • A tear in the wall of the uterus
  • Breast tenderness
  • Blurred vision
  • Coughing
  • Rash
  • Stiff neck
  • Dehydration
  • Tremor
  • Tingling, pricking, burning, or numbness of the skin
  • Hearing problems
  • Difficulty urinating
  • Sore throat
  • Hoarseness
  • Sweating
  • Eye pain
  • Wheezing
  • An abnormal heartbeat (arrhythmia)
  • Skin discoloration
  • Tension in the vaginal muscles.
Pregnancy and Pain

Dinoprostone Drug Information

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