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Dinoprostone and Breastfeeding

Although it is unknown whether dinoprostone passes through human breast milk, this drug is usually given intravaginally right before childbirth or after a pregnancy has ended. Therefore, it is unlikely that a woman would receive dinoprostone while breastfeeding. However, if the drug is to be given to a woman who is nursing, it might affect breast milk production during the first few days after delivery.

Can Breastfeeding Women Use Dinoprostone?

It is currently unknown whether dinoprostone (Cervidil®, Prepidil®, Prostin E2®) passes through breast milk in humans. If you are breastfeeding, talk with your healthcare provider before receiving this drug.

More Information on Dinoprostone and Breastfeeding

There is currently no research on the use of dinoprostone in breastfeeding women. Therefore, it is unknown whether the medication passes through breast milk, or whether it would harm a nursing child.
Dinoprostone is a hormone-type substance known as a prostaglandin. Prostaglandins are naturally found in breast milk in small amounts, where they are thought to help protect the infant's gastrointestinal tract.
When given by mouth in the first few days after birth, dinoprostone can suppress breast milk production. However, by one month after birth, the drug no longer has an effect on lactation. It is unknown whether intravaginally administered dinoprostone would have the same effects.
If this medication is to be given to women who are nursing, it may be safest to avoid using it in the first few days after delivery to avoid any unwanted effects on milk production. However, based on its normal uses, dinoprostone is unlikely to be used in the first few days after birth anyhow, or in breastfeeding women at all. In addition, because the medication is given intravaginally and not by mouth, the actions of the drug may be short enough that it does not affect breast milk.
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Dinoprostone Drug Information

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