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Dinoprostone Vaginal Suppository Side Effects

Common Side Effects

For many medications, the prescribing information carefully explains the exact percentage of side effects that were reported during clinical trials. However, the prescribing information for almost all older medications, including the dinoprostone vaginal suppository, includes only general estimates about possible side effects, without exact percentages.
In clinical studies, the most common dinoprostone vaginal suppository side effects included:
  • Vomiting -- in up to 67 percent of people
  • Fever -- up to 50 percent
  • Diarrhea -- up to 40 percent
  • Nausea -- up to 33 percent
  • Headache -- up to 10 percent
  • Shivering and chills -- up to 10 percent.
Other reported reactions included but were not limited to:
  • Backache
  • Joint swelling, aches, or pain
  • Flushing (a sudden warmth and redness of the face, neck, and chest)
  • Dizziness and fainting
  • Muscle aches, cramps, or pain
  • Vaginal pain
  • Shortness of breath
  • Endometriosis (when cells from the lining of the womb grow in other areas of the body)
  • Vaginal inflammation or infection
  • Weakness
  • Nighttime leg cramps
  • A tear in the wall of the uterus
  • Breast tenderness
  • Blurred vision
  • Coughing
  • Rash
  • Stiff neck
  • Dehydration
  • Tremors
  • Tingling, pricking, burning, or numbness of the skin
  • Hearing problems
  • Difficulty urinating
  • Sore throat
  • Hoarseness
  • Sweating
  • Eye pain
  • Wheezing
  • An abnormal heartbeat (arrhythmia)
  • Skin discoloration
  • Tension in the vaginal muscles.
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Dinoprostone Vaginal Suppository Information

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