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What Is Dinoprostone Vaginal Insert Used For?

How Does This Medicine Work?

Dinoprostone vaginal inserts are a manufactured (synthetic) version of a hormone in the body known as prostaglandin E2. Prostaglandin E2 is naturally secreted by the fetus and placenta during pregnancy, and plays an important role in the steps leading to labor. Importantly, the hormone is involved in cervical ripening, which is when the cervix softens and relaxes to allow passage of the baby during birth.
The dinoprostone vaginal insert slowly releases medication over a 12-hour period. The effects of the medication are expected to reverse quickly after the insert is removed.

Can Children Use Dinoprostone Vaginal Inserts?

Dinoprostone vaginal inserts are only approved for use in adult women of reproductive age who are pregnant. These inserts have not been studied in adolescents of childbearing age. However, adolescents are expected to respond to the medication no differently than adult women.

What About Off-Label Uses?

On occasion, healthcare providers may recommend medications for something other than the approved uses. This is called an "off-label" use. At this time, there are no well-accepted, off-label uses for dinoprostone vaginal inserts.
Pregnancy and Pain

Dinoprostone Vaginal Insert Information

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