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Dinoprostone Vaginal Insert

What If I Overdose on This Medicine?

An overdose of this medication could cause increased uterine contractions and fetal distress. If you receive too much, seek immediate medical attention.
(Click Cervidil Overdose for more information.)

What If I Miss a Dose?

Because this medication is given by your healthcare provider when you are near the time of delivery (see Cervidil and Pregnancy), it is unlikely that you will miss a dose.

How Does This Medicine Work?

Dinoprostone vaginal inserts are a manufactured (synthetic) version of a hormone in the body known as prostaglandin E2. Prostaglandin E2 is naturally secreted by the fetus and placenta during pregnancy, and plays an important role in the steps leading to labor. Importantly, the hormone is involved in cervical ripening, which is when the cervix softens and relaxes to allow passage of the baby during birth.
The dinoprostone vaginal insert slowly releases medication over a 12-hour period. The effects of the medication are expected to reverse quickly after the insert is removed.

Clinical Effects

In one clinical study, 65 percent of women were more likely to go into labor or deliver a baby vaginally within 12 hours of receiving a dinoprostone vaginal insert, compared with 28 percent of women who received a placebo (a similar product that did not contain any active ingredients). Women who received a dinoprostone vaginal insert also went into labor about 19.5 hours sooner than women who received a placebo.
Pregnancy and Pain

Dinoprostone Vaginal Insert Information

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