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Drug Interactions With Dextromethorphan and Quinidine

Taking certain medications with dextromethorphan and quinidine may result in dangerous (and even life-threatening) complications. Some of these interactions can increase your risk for potentially serious side effects or decrease the effectiveness of the medications. Alcohol, antacids, and grapefruit juice are among the products that can lead to negative drug interactions with dextromethorphan and quinidine.

An Overview of Dextromethorphan and Quinidine Interactions

Dextromethorphan and quinidine (Nuedexta™) may potentially interact with many other medications, far too many to list completely in this article. This article includes some of the more common and dangerous drug interactions.
Some of the drugs that may lead to reactions with dextromethorphan and quinidine include but are not limited to:
  • Carbonic anhydrase inhibitors, such as:
    • Acetazolamide (Diamox®)
    • Dichlorphenamide (Daranide®)
    • Methazolamide
  • Certain statin medications, such as:


  • CYP 3A4 inducer medications, such as:


  • CYP 3A4 inhibitor medications, such as:




    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)




  • Neuromuscular-blocking medications, such as:


    • Atracurium
    • Cisatracurium (Nimbex®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Vecuronium (Norcuron®)
  • P-glycoprotein inducers, such as:


  • P-glycoprotein inhibitors, such as:










Know the Signs - Concussion Safety

Dextromethorphan and Quinidine Information

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