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Drug Interactions With Dextromethorphan and Quinidine

Neuromuscular-Blocking Medications
There have been cases of increased neuromuscular-blocking effects, such as decreased breathing, in people taking quinidine (one of the active ingredients in dextromethorphan and quinidine) who also received a neuromuscular-blocking medication. Neuromuscular-blocking agents are normally used during surgery. If you are taking dextromethorphan and quinidine and have an upcoming surgery, discuss this with your healthcare provider.
 
P-Glycoprotein (Pgp) Inducers
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, out of body tissues so they can be excreted through the urine or feces. Pgp helps remove dextromethorphan and quinidine from the body. Certain other medications (known as Pgp inducers) increase the activity of Pgp.
 
Taking dextromethorphan and quinidine with one of these Pgp inducers causes the drug to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take dextromethorphan and quinidine with a Pgp inducer, to make sure it is working for you.
 
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove dextromethorphan and quinidine from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
 
Taking dextromethorphan and quinidine with one of these Pgp inhibitors causes the drug to be removed more slowly, potentially increasing the amount of dextromethorphan and quinidine in your body and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take dextromethorphan and quinidine with a Pgp inhibitor.
Know the Signs - Concussion Safety

Dextromethorphan and Quinidine Information

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