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Drug Interactions With Dextromethorphan and Quinidine

Malaria Medications
Taking dextromethorphan and quinidine with antimalarial medications increases the risk of QT prolongation, a dangerous type of arrhythmia. Talk to your healthcare provider about this possible interaction before taking these medications together. In general, dextromethorphan and quinidine should not be taken with quinidine, quinine, or mefloquine.
 
Maraviroc
Dextromethorphan and quinidine may increase the level of maraviroc in your body, increasing your risk for side effects. Your healthcare provider may choose to lower your maraviroc dose. People with severe kidney disease should not take maraviroc with dextromethorphan and quinidine.
 
QT-Prolonging Medications
Dextromethorphan and quinidine can cause QT prolongation, a potentially dangerous heart rhythm problem. In general, dextromethorphan and quinidine should not be combined with any other medications that can cause QT prolongation, due to the risk of a life-threatening arrhythmia.
 
Methylprednisolone
Dextromethorphan and quinidine can increase methylprednisolone blood levels, increasing the risk for potentially serious side effects. If you take these medications together, your healthcare provider may lower your methylprednisolone dose and monitor you more closely.
 
Mometasone Inhaler
Normally, only a small amount of inhaled mometasone is absorbed into the body. However, when used with dextromethorphan and quinidine, mometasone blood levels may increase. This could increase your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking dextromethorphan and quinidine with MAOIs can increase your chance of developing a potentially life-threatening problem known as serotonin syndrome. Do not take dextromethorphan and quinidine if you have taken an MAOI within the past two weeks. Also, wait two weeks after stopping dextromethorphan and quinidine before taking an MAOI.
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Dextromethorphan and Quinidine Information

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