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Drug Interactions With Dextromethorphan and Quinidine

Fentanyl
Combining fentanyl with dextromethorphan and quinidine may increase the level of fentanyl in your body, increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Your healthcare provider may monitor you more closely for side effects if you take fentanyl with dextromethorphan and quinidine.
 
Fesoterodine
Combining dextromethorphan and quinidine with fesoterodine may increase the amount of fesoterodine in your body, increasing your risk for side effects. It general, people who take dextromethorphan and quinidine should not take more than 4 mg of fesoterodine. Talk to your healthcare provider about this potential interaction, as you may need a lower fesoterodine dose.
 
Guanfacine
Dextromethorphan and quinidine may increase the levels of guanfacine in your blood, increasing your risk for side effects, such as low blood pressure and a slow heart rate. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Hydrocodone
Dextromethorphan and quinidine can make hydrocodone less effective at controlling pain. Your healthcare provider may choose to monitor your pain level more closely if you take these medications together to make sure hydrocodone is working for you.
 
Linezolid
Linezolid is an antibiotic that has monoamine oxidase inhibitor (MAOI) properties. Because dextromethorphan and quinidine should not be taken within two weeks of an MAOI, it is important for people who take (or have recently taken) linezolid to not use dextromethorphan and quinidine.
 
Lurasidone
Combining dextromethorphan and quinidine with lurasidone may increase the level of lurasidone in your blood, increasing your risk for potentially serious side effects. In general, these medications should not be taken together.
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Dextromethorphan and Quinidine Information

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