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Drug Interactions With Dextromethorphan and Quinidine

Colchicine
Dextromethorphan and quinidine increases blood levels of colchicine, which could increase your risk for potentially serious colchicine side effects. Do not take these medications without first talking to your healthcare provider. You may need a lower colchicine dose.
 
CYP 2D6 Inhibitors
The body breaks down dextromethorphan and quinidine using enzymes in the liver known as CYP 2D6 enzymes. Some other medications (known as CYP 2D6 inhibitors) can decrease the activity of these enzymes. Combining dextromethorphan and quinidine with one of these CYP 2D6 inhibitors may increase the level of dextromethorphan and quinidine in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you take it with a CYP 2D6 inhibitor.
 
CYP 3A4 Inducer Medications
The body breaks down dextromethorphan and quinidine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining dextromethorphan and quinidine with one of these CYP 3A4 inducers may decrease the level of dextromethorphan and quinidine in your body, making it less effective. Your healthcare provider may need to monitor you more closely.
 
CYP 3A4 Inhibitor Medications
The body breaks down dextromethorphan and quinidine using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining dextromethorphan and quinidine with one of these CYP 3A4 inhibitors may increase the level of dextromethorphan and quinidine in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely.
 
Dabigatran
Combining dextromethorphan and quinidine with dabigatran could increase your dabigatran blood levels, increasing your risk for bleeding. Talk to your healthcare provider before taking these medications together.
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Dextromethorphan and Quinidine Information

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