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Drug Interactions With Dextromethorphan and Quinidine

Sibutramine
Taking dextromethorphan and quinidine with sibutramine can increase your risk for a serious reaction known as serotonin syndrome (see Precautions and Warnings With Dextromethorphan and Quinidine for more information, including symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome.
 
Silodosin
Taking dextromethorphan and quinidine with silodosin can raise the level of silodosin in your blood, increasing your risk for serious side effects. In general, these medications should not be used together.
 
St. John's Wort
Taking dextromethorphan and quinidine with St. John's Wort can increase your risk for a serious reaction known as serotonin syndrome (see Precautions and Warnings With Dextromethorphan and Quinidine for more information, including symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome.
 
Sucralfate
Taking dextromethorphan and quinidine with sucralfate may decrease the amount of dextromethorphan and quinidine absorbed into the body, which could make it less effective. Dextromethorphan and quinidine should be taken at least two hours before or six hours after sucralfate.
 
Tadalafil
Dextromethorphan and quinidine may increase the level of tadalafil in the blood, which could increase your risk for side effects. If you take dextromethorphan and quinidine, your healthcare provider may choose to give you a lower tadalafil dose.
Know the Signs - Concussion Safety

Dextromethorphan and Quinidine Information

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