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What Is Dexlansoprazole Used For?

How Does It Work?

Dexlansoprazole belongs to a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. Dexlansoprazole works by binding to the proton pumps, stopping them from producing acid. PPIs are very effective at decreasing acid production, since they work directly at the acid pumps.
Dexlansoprazole capsules contain tiny delayed-release granules that contain the medication. They are specially designed to release the medication in two different phases. The first "peak" occurs one to two hours after the medication is taken, and the second peak occurs within four to five hours. Additionally, the delayed-release granules are also enteric coated, which means they have a special coating to protect them from stomach acid (since the medication can be destroyed by stomach acid). The coating protects the medication until it reaches the small intestine, where the medication can be absorbed.

Uses of Dexlansoprazole in Children

Dexlansoprazole has not been approved for use in children, as it has not been adequately studied in individuals under 18 years of age.

Off-Label Uses

On occasion, your healthcare provider may recommend dexlansoprazole for treating something other than the conditions listed in this article. This is called an "off-label" use. Some off-label uses of dexlansoprazole may include:
  • Treating ulcers, including stomach ulcers (gastric ulcers) or small intestine ulcers (duodenal ulcers)
  • Preventing ulcers due to nonsteroidal anti-inflammatory medications (NSAIDS)
  • Preventing "stress ulcers" in people hospitalized in an intensive care unit (ICU)
  • Treating pathological hypersecretory conditions, such as:


    • Zollinger-Ellison syndrome
    • Multiple endocrine adenomas
    • Systemic mastocytosis
    • "Short-gut" syndrome.

Dexlansoprazole Drug Information

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