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Precautions and Warnings With Dexlansoprazole

There are many precautions and warnings with dexlansoprazole to be aware of, including knowing who should not use this medication. If you have liver disease, let your healthcare provider know before starting dexlansoprazole, as you may need a lower dosage. Since the full risks of using dexlansoprazole during pregnancy are not known, you should also tell your healthcare provider if you are pregnant.

What Should I Tell My Healthcare Provider Before Taking Dexlansoprazole?

You should talk with your healthcare provider prior to taking dexlansoprazole (Dexilant™) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including allergies to other beta blockers, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Dexlansoprazole Warnings and Precautions

Warnings and precautions to be aware of prior to taking dexlansoprazole include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as dexlansoprazole) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 



  • Proton pump inhibitors (PPIs), including dexlansoprazole, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Dexlansoprazole can interact with other medications (see Drug Interactions With Dexlansoprazole).
  • Dexlansoprazole is considered a pregnancy Category B medication. This means that dexlansoprazole is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using dexlansoprazole during pregnancy (see Kapidex and Pregnancy).
  • It is unknown if dexlansoprazole passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Kapidex and Breastfeeding).

Dexlansoprazole Drug Information

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