• There are certain medications that desloratadine and pseudoephedrine can interact with (see Drug Interactions With Desloratadine and Pseudoephedrine).
   
• Although desloratadine and pseudoephedrine causes drowsiness less often than other antihistamines, it can still make some people tired. Therefore, until you know whether desloratadine and pseudoephedrine makes you tired, caution should be used before driving a car or operating potentially dangerous machinery.
   
• Desloratadine and pseudoephedrine is a pregnancy Category C medicine, meaning that it could potentially harm your unborn child. If you are pregnant, you should only take desloratadine and pseudoephedrine if the benefit outweighs the possible risk to your unborn child. Before using the drug, discuss its safety with your healthcare provider.
   
• If you are nursing or plan to nurse, desloratadine and pseudoephedrine passes through your milk. Therefore, if you are taking it, you should stop nursing until talking with your doctor.
   

• Are allergic to desloratadine and pseudoephedrine, Clarinex-D, Claritin, loratadine, adrenergic agents, or any of the inactive components used in making the drug. Your healthcare provider or pharmacist has a list of the inactive ingredients.
   
• Have narrow-angle glaucoma.
   
• Have urinary blockage or difficulty urinating.
   
• Are taking an MAO inhibitor or have taken an MAO inhibitor within the last 14 days. MAO inhibitors are medicines used to treat depression. Some examples of MAO inhibitors include:

o Isocarboxazid (Marplan^®)

o Phenelzine (Nardil^®)

o Selegiline (Eldepryl^®, EMSAM^®)

o Tranylcypromine (Parnate^®).

•  Have severe high blood pressure (hypertension).
•  Have severe coronary heart disease.