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Drug Interactions With Dalfampridine

There are currently no known drug interactions with dalfampridine. Research has shown that this medication travels through the body without being fully broken down (metabolized) by the liver. Therefore, it is not likely to interact with other medications. However, there may still be interactions that have not yet been discovered, so make sure your healthcare provider is aware of any other medications you are taking.

Does Dalfampridine Interact With Other Drugs?

Dalfampridine (Ampyra™) is a prescription medication licensed to improve walking in people with multiple sclerosis (MS). It is a potassium channel blocker. At this time, no drug interactions with dalfampridine have been identified.
Studies have shown that most of a dose of dalfampridine is excreted through the urine unchanged. This means that the medication travels through the body and is removed from the body (by the kidneys through the urine), mostly without being metabolized (broken down) by the liver. Because it is not metabolized significantly, it is unlikely to be affected by other drugs that would affect liver metabolism (this is a major way that many drugs interact).
It should be noted that dalfampridine should not be taken with compounded 4-aminopyridine or fampridine, as such medications already contain dalfampridine (4-aminopyridine and fampridine are other names for dalfampridine).

Final Thoughts on Dalfampridine Drug Interactions

In clinical studies of dalfampridine, no drug interactions have been identified. However, this does not necessarily imply that there really are no drug interactions with this product. This medication has not been studied with every possible drug, and there may be drug interactions that are discovered at a later date. However, at this time dalfampridine seems unlikely to cause drug interactions.
Nonetheless, it is always a good idea to give your healthcare provider a complete list of all medications you are taking, including prescription drugs, nonprescription drugs, and herbs and supplements.
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Dalfampridine Drug Information

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