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How Does Dalfampridine Work?

Dalfampridine blocks potassium channels. Potassium channels are found throughout the body and have several different functions, including playing an important role in how nerves work. It is thought that dalfampridine helps nerve signals travel down the nerves that have been damaged by MS.

Clinical Effects

Clinical studies have shown that dalfampridine can improve walking speed in people with MS. For instance, in one study, over 30 percent of people taking dalfampridine had a 20 percent or greater increase in walking speed, compared to only about 10 percent of people taking a placebo (a "sugar pill" with no active ingredients).

When and How to Take Dalfampridine

Some general considerations include the following:
  • Dalfampridine comes in extended-release tablet form. It is usually taken by mouth twice a day.
  • This medication can be taken with or without food. Try taking it with food if it seems to bother your stomach.
  • Do not crush, chew, or break the tablets; make sure to swallow them whole.
  • Try to take your doses about 12 hours apart to keep an even level of dalfampridine in your bloodstream.
  • For this drug to work properly, it must be taken as prescribed.

How Should This Medicine Be Stored?

Dalfampridine should be stored at room temperature, away from moisture and heat. Keep this and all other medications out of the reach of children.

What Should I Do If I Miss a Dose?

If you forget to take a dose of dalfampridine, simply skip your missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine.
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Dalfampridine Drug Information

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