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Drug Interactions With Colesevelam

More Information on Interactions With Colesevelam Explained

The following sections explain in detail the potentially negative interactions that can occur when colesevelam is combined with any of the drugs listed above.
 
Certain Vitamins
Colesevelam may decrease the absorption of fat-soluble vitamins, such as vitamin A, vitamin D, vitamin E, and vitamin K. You should take any such vitamins at least four hours before a dose of colesevelam.
 
Cyclosporine
Colesevelam can decrease the absorption of cyclosporine. You should take cyclosporine at least four hours before colesevelam, and your healthcare provider should monitor the level of cyclosporine in your blood and adjust your dosage as necessary.
 
Glimepiride
Colesevelam may decrease the absorption of glimepiride into the body, perhaps making it less effective. Glimepiride should be taken at least four hours before a dose of colesevelam to avoid this interaction. If you take colesevelam twice a day and have trouble timing the doses of glimepiride and colesevelam, ask your healthcare provider about taking colesevelam just once a day instead of twice a day, as this can help make avoiding this interaction easier.
   
Glyburide (DiaBeta, Glynase, Micronase)
Colesevelam may decrease the absorption of glyburide into the body, perhaps making it less effective. Glyburide should be taken at least four hours before a dose of colesevelam to avoid this interaction. If you take colesevelam twice a day and have trouble timing the doses of glyburide and colesevelam, ask your healthcare provider about taking colesevelam just once a day instead of twice a day, as this can make avoiding this interaction easier.
 
Levothyroxine (Levoxyl, Levothroid, Synthroid, Tirosint, Unithroid)
Colesevelam may decrease the absorption of levothyroxine into the body, perhaps making it less effective. Levothyroxine should be taken at least four hours before a dose of colesevelam to avoid this interaction.
 
Metformin ER
Colesevelam may increase the level of metformin ER in the bloodstream, perhaps increasing the risk for metformin ER side effects. Check with your healthcare provider before combining these medications. You may need to monitor your blood sugar more closely for a while.
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Colesevelam Medicine

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