Drug Interactions With Cetirizine and Pseudoephedrine

Digoxin, rasagiline, and phenelzine are among the medications that can cause drug interactions with cetirizine and pseudoephedrine. These interactions could cause your body to metabolize the drugs differently than intended and cause some drugs to become less effective. Prior to taking the allergy medication, talk with your healthcare provider about any drug interactions with cetirizine and pseudoephedrine that may apply to you.

Drug Interactions With Cetirizine and Pseudoephedrine: An Overview 

Cetirizine and pseudoephedrine (Zyrtec-D®) can potentially interact with a few other medications. Some of the medicines that may lead to drug interactions with cetirizine and pseudoephedrine include:
 
 
  • Stimulants, such as cocaine, amphetamines, and many attention deficit hyperactivity disorder (ADHD) medications.
     

More Information on Interactions With Cetirizine and Pseudoephedrine

The following sections explain in detail the potentially negative interactions that can occur when cetirizine and pseudoephedrine is combined with any of the drugs listed above.
 
Blood Pressure Medications
Cetirizine and pseudoephedrine may make blood pressure medications less effective, possibly causing high blood pressure (hypertension). This is due to the pseudoephedrine component of the drug. If you take high blood pressure medications, check with your healthcare provider before taking cetirizine and pseudoephedrine, or try plain Zyrtec® instead, which does not contain pseudoephedrine and does not increase blood pressure.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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