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Certolizumab Pegol

What Should I Tell My Healthcare Provider Before Taking Certolizumab Pegol?

You should talk with your healthcare provider prior to taking certolizumab pegol if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Certolizumab Pegol to learn more, including information on who should not take the drug.)

How Does It Work?

Certolizumab pegol belongs to a group of drugs called tumor necrosis factor (TNF) blockers. There are different types of TNF, and certolizumab pegol binds preferentially to TNF-alpha. TNF-alpha is a naturally occurring chemical in the body that is involved in inflammation and other immune system functions. TNF-alpha can contribute to a number of inflammatory diseases, such as Crohn's disease, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and people with these conditions often have high TNF-alpha levels. Blocking TNF-alpha helps to decrease the inflammation and to relieve the signs and symptoms of these diseases.
Interestingly, certolizumab pegol is actually a fragment of a human antibody. It is produced in special bacteria that were designed to produce this human antibody fragment. The antibody fragment is then "pegylated," which means it is attached to a polyethylene glycol molecule. This process helps certolizumab pegol stay in the body longer (so it can be taken less often).
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Certolizumab Pegol Information

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