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Carmustine Implant Side Effects

Common Side Effects

The carmustine implant has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the implants were carefully documented and compared to those that occurred in a similar group of people given a placebo (an implant that did not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common carmustine implant side effects included:
  • Worsening of health or the condition being treated, such as progression of the tumor or cancer -- in up to 82 percent of people
  • Paralysis on one side of the body -- up to 41 percent
  • Seizures -- up to 33 percent
  • Headache -- up to 28 percent
  • Confusion -- up to 23 percent
  • Swelling around the brain -- up to 23 percent
  • Weakness or lack of energy -- up to 22 percent
  • Nausea -- up to 22 percent
  • Vomiting -- up to 21 percent
  • Constipation -- up to 19 percent.
Other common reactions, occurring in 1 percent to 18 percent of people, included but were not limited to:
  • Infections, including pneumonia and urinary tract infections (UTI, such as a bladder infection)
  • Fever
  • Speech problems
  • Abnormal healing of wounds
  • Pain
  • Rash
  • Drowsiness
  • Blood clots in a vein or the lungs
  • Hair loss (alopecia)
  • Swelling of the arms, hands, legs, ankles, or feet
  • Loss of memory
  • Increased brain pressure
  • Abdominal (stomach) pain
  • Loss of bladder control (incontinence)
  • Changes in personality
  • Changes in mood, such as depression or anxiety
  • Back pain
  • Internal bleeding
  • Paralysis of the face
  • Numbness, tingling, or pricking sensations
  • Swelling of the face
  • Vision problems, such as double vision or blurry vision
  • Problems with movement, balance, or coordination
  • Abnormal thinking
  • Diarrhea
  • Abscess (a collection of pus in a swollen area of the body)
  • Accidental injury
  • Chest pain
  • Diabetes
  • Tremor
  • Dizziness
  • Seeing or hearing things that are not real (hallucinations)
  • Brain infection, such as meningitis or brain abscess
  • Muscle weakness
  • Coma
  • Cushing's syndrome
  • Shortness of breath
  • An allergic reaction
  • Abnormal liver function tests, which could be a sign of liver problems.
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Carmustine Implant Information

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