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Cancer and Polifeprosan 20 Carmustine Implant

People with certain types of brain tumors may receive chemotherapy treatment with a drug called carmustine implant (Gliadel®). This prescription medicine is specifically used to treat malignant glioma or glioblastoma multiforme in adults.
Carmustine implants come as small, dime-sized wafers that are surgically implanted into the brain. The wafers are placed into the space that remains after a brain tumor is removed.
The carmustine implant is sometimes called polifeprosan 20 with carmustine implant. Polifeprosan 20 is a biodegradable molecule used to control the delivery of the active drug in the implant. As polifeprosan 20 degrades (breaks down), it releases carmustine into the brain. Carmustine works to prevent cancer cells from growing and multiplying by interfering with the replication process of DNA.
(To learn more, click What Is Carmustine Implant Used For?. This full-length article examines specific uses for this chemotherapy drug, including the types of cancer it is used to treat and more details on how it works.)
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