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Drug Interactions With Carfilzomib

If you are using aripiprazole, clozapine, or pimozide medications, talk to your healthcare provider about whether these products may cause drug interactions with carfilzomib. In some cases, this chemotherapy medicine can cause negative reactions with products such as these, possibly increasing your risk for side effects, serious infections, or other potentially dangerous complications.


An Overview of Carfilzomib Interactions

Carfilzomib (Kyprolis™) can potentially react with a few other medications. Some of the products that may lead to drug interactions with carfilzomib include but are not limited to:

More Detail on Drug Interactions With Carfilzomib

The following sections explain in detail the potentially negative interactions that can occur when carfilzomib is combined with any of the drugs listed above.
Carfilzomib may increase blood levels of aripiprazole, which could increase your risk for aripiprazole side effects. If you use these medicines together, let your healthcare provider know if you may be experiencing more side effects. He or she may choose to adjust your aripiprazole dosage.
Taking clozapine with carfilzomib may increase the risk for dangerously low white blood cells, which would increase your risk for potentially serious infections. Talk to your healthcare provider before using these medicines together. Do not stop taking clozapine, however, unless your healthcare provider specifically tells you to do so.
Carfilzomib may increase blood levels of pimozide, which could increase the risk for potentially serious pimozide side effects. Talk to your healthcare provider about this potential interaction before using these drugs together.  
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