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Carfilzomib Dosage

When prescribing carfilzomib, the dosage will vary for each person, depending on his or her weight, response to the medication, and various other factors. This injection is given slowly into a vein once a day for two consecutive days every seven days. After six doses, you receive a break in treatment. The medicine is administered by a healthcare provider in a healthcare setting.


An Introduction to Your Dosage of Carfilzomib

The dose of carfilzomib (Kyprolis™) your healthcare provider recommends will vary, based on a number of factors, such as:
  • Your height and weight
  • How well you tolerate the medication.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Recommended Carfilzomib Dosing Guidelines

Carfilzomib is normally dosed in 28-day treatment cycles, during which time the drug is administered once a day for two consecutive days every seven days. This means you will receive your carfilzomib doses on days 1, 2, 8, 9, 15, and 16 of the 28-day treatment cycle. After the sixth dose (day 16), you will be given a 12-day break (days 17 to 28), during which time you will not receive any carfilzomib.
Like many chemotherapy medicines, actual doses of carfilzomib are based on body surface area, which is calculated using your height and weight. Doses based on body surface area are written as milligrams per meter squared (mg per m2). The usual recommended amount of carfilzomib in the first treatment cycle (cycle 1) is 20 mg per m2 per dose. If this amount is tolerated, it may be increased to 27 mg per m2 per dose beginning in cycle 2.
Your healthcare provider will monitor you closely for side effects during treatment, and may lower your dose or recommend you skip a dose if you develop potentially serious side effects. Treatment normally continues until the cancer progresses or unacceptable side effects occur.  
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Carfilzomib Drug Information

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