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What Is Canakinumab Used For?

Canakinumab for SJIA

Systemic juvenile idiopathic arthritis (also known as systemic juvenile rheumatoid arthritis) is a form of rheumatoid arthritis that begins in childhood. In juvenile idiopathic arthritis, the immune system begins to attack the body (including the joints), causing pain.
There are several different types of juvenile idiopathic arthritis. With the systemic type, the entire body can be affected, with additional symptoms such as unexplained rashes, fever, and internal organ problems. Nonsystemic types include the polyarticular and oligoarticular types. 
Canakinumab is approved to treat active systemic juvenile idiopathic arthritis in individuals age two years and older.

How Does It Work?

Canakinumab is a manufactured antibody (a protein normally produced by the immune system). It works by blocking the actions of interleukin-1 beta (IL-1β), a protein that causes inflammation in the body. People with CAPS or SJIA have increased levels of IL-1β. By blocking its action, canakinumab reduces the inflammation and symptoms associated with CAPS or SJIA.

Can Children Use Canakinumab?

Canakinumab is approved for use in children as young as four years old for CAPS or as young as two years old for SJIA. Talk to your child's healthcare provider about the risks and benefits of using this medicine in children.

Is It Safe for Older Adults?

There were not enough older adults in clinical trials on canakinumab to say for certain whether older adults will respond to the medicine in the same way as younger age groups. In general, older adults may have an increased risk for certain canakinumab side effects, and therefore may need more careful monitoring.
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Canakinumab Drug Information

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