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Canakinumab

Drug Interactions

Canakinumab may react with a few other medicines (see Drug Interactions With Canakinumab).
 

What If I Overdose on This Medicine?

It is not entirely clear what to expect from an overdose with this medicine. Seek immediate medical attention if you believe you have received too much canakinumab.
 
(Click Ilaris Overdose for more information.)
 

What If I Forget a Dose of Canakinumab?

If you miss an appointment to receive your canakinumab dose, contact your healthcare provider as soon as you remember to reschedule. It is important to try and remember all of your appointments while receiving this medicine.
 

How Does It Work?

Canakinumab is a manufactured antibody (a protein normally produced by the immune system). It works by blocking the actions of interleukin-1 beta (IL-1β), a protein that causes inflammation in the body. People with CAPS or SJIA have increased levels of IL-1β. By blocking its action, canakinumab reduces the inflammation and symptoms associated with CAPS or SJIA.
 

Clinical Effects

In a clinical study, canakinumab was shown to reduce symptoms of CAPS. In the study, 97 percent of people had minimal symptoms or improved symptoms after eight weeks of treatment. No one in the study experienced a flare-up of symptoms over eight months of treatment.
 
In clinical studies of canakinumab for SJIA, children or adolescents given canakinumab had symptom reduction, as well as a better chance to decrease or eliminate their corticosteroids, compared to a placebo (an injection with no active ingredients). 
 
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Canakinumab Drug Information

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