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Cabozantinib Side Effects

Some of the possible side effects of cabozantinib include diarrhea, ulcers, and fatigue. Studies have shown that most people who use this drug will develop some type of reaction. Because cabozantinib is associated with potentially serious problems, such as dangerous infections and unusual bleeding, let your healthcare provider know immediately if you develop something that doesn't seem right.

 

An Introduction to Side Effects of Cabozantinib

Just like any chemotherapy medicine, cabozantinib (Cometriq™) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some problems can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
 
(This article covers many, but not all, of the possible side effects with cabozantinib. Your healthcare provider can discuss a more complete list with you.)
 

Serious Cabozantinib Side Effects

Some side effects of cabozantinib are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
 
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
 
  • Severe or persistent diarrhea
  • Blisters, sores, redness, swelling, pain, or peeling of the skin on the palms of the hands or soles of the feet
  • Ulcers, sores, pain, or swelling in the mouth, especially if it prevents you from eating and drinking
  • Jaw pain or toothache
  • Any abnormal or unusual bleeding, or signs of bleeding problems, such as:
    • Coughing up blood
    • Black, tarry, or bloody stools
    • Vomiting blood or vomit that looks like coffee grounds
    • Heavier-than-normal menstrual bleeding in women
 
  • Severe abdominal (stomach) pain
  • Coughing, gagging, or choking when eating or drinking
  • Signs of blood clots, such as:
    • Warmth, swelling, or pain in an arm or leg
    • Shortness of breath
    • Chest pain
 
  • Signs of a stroke, such as:
    • Difficulty seeing, speaking, or walking
    • Confusion
    • Loss of coordination or balance
    • Weakness in your face, arm, or leg
    • A severe headache
 
  • Signs of a heart attack, such as:
    • Chest pain or discomfort
    • Shortness of breath
    • Sweating
    • Nausea
    • Feeling lightheaded or faint
 
  • Wounds that don't heal or heal slowly
  • High blood pressure (hypertension)
  • Swelling of the arms, hands, legs, ankles, or feet
  • Significant weight loss
  • Signs of a serious condition known as reversible posterior leukoencephalopathy syndrome (RPLS), such as:
 
  • Signs of infection, such as:
 
  • Yellowing of the skin or whites of the eyes (jaundice).
 
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Cabozantinib Drug Information

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