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Precautions and Warnings With Buprenorphine and Naloxone

Before starting treatment with buprenorphine and naloxone, tell your healthcare provider if you have breathing problems, any allergies, or a history of seizures. Also, if you are pregnant or breastfeeding, you may not be able to take buprenorphine and naloxone. Warnings and precautions also apply to people who are taking certain medications, vitamins, and herbal supplements.

What Should I Tell My Healthcare Provider Before Using Buprenorphine and Naloxone?

Talk with your healthcare provider prior to using buprenorphine and naloxone (Suboxone®) if you have:
 
  • A history of breathing problems, asthma, chronic obstructive pulmonary disease (COPD), or any other lung disease
  • Heart disease of any kind
  • An irregular heart rhythm (arrhythmia)
  • A slow heart rate (bradycardia)
  • A head injury, brain tumor, or increased pressure around the brain
  • A history of a stroke
  • A history of a seizure
  • Problems urinating
  • Low blood pressure (hypotension)
  • Gallbladder or pancreas disease
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
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Buprenorphine and Naloxone Drug Information

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