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Drug Interactions With Buprenorphine and Naloxone

Drug Interactions With Buprenorphine and Naloxone Explained

The following sections explain in detail the potentially negative reactions that can occur when buprenorphine and naloxone is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using buprenorphine and naloxone could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using buprenorphine and naloxone.
 
Benzodiazepines
Combining buprenorphine and naloxone with a benzodiazepine may increase the risk for serious problems, including death, particularly in the case of abuse or overdose. Normally, there is a limit, known as a "ceiling," to how much buprenorphine and naloxone can negatively affect breathing. However, benzodiazepines may increase this limit, allowing for dangerously slow or irregular breathing. Do not combine buprenorphine and naloxone with a benzodiazepine without your healthcare provider's approval and supervision.
 
CYP 3A4 Inducer Medications
The liver breaks down buprenorphine and naloxone using enzymes known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining buprenorphine and naloxone with one of these CYP 3A4 inducers may decrease the level of buprenorphine and naloxone in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure buprenorphine and naloxone is still working effectively if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down buprenorphine and naloxone using enzymes known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining buprenorphine and naloxone with one of these CYP 3A4 inhibitors may increase the level of buprenorphine and naloxone in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing difficulty. Your healthcare provider may monitor you more closely for side effects if you take buprenorphine and naloxone with a CYP 3A4 inhibitor.
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Buprenorphine and Naloxone Drug Information

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