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Buprenorphine and Naloxone Side Effects

Common Side Effects

Buprenorphine and naloxone has been studied extensively in clinical trials. In these studies, the side effects were carefully documented.
Based on the information from these studies, the most common buprenorphine and naloxone side effects included:
  • Headaches -- in up to 36.4 percent
  • Pain -- up to 22.4 percent
  • Nausea -- up to 15 percent
  • Sweating -- up to 14 percent
  • Constipation -- up to 12.1 percent
  • Abdominal (stomach) pain -- up to 11.2 percent
  • Flushing or hot flashes -- up to 9.3 percent
  • Vomiting -- up to 7.5 percent
  • General feeling of weakness -- up to 6.5 percent.
Buprenorphine and naloxone may cause opioid withdrawal symptoms, particularly if used by people who are still taking other opioids. This effect is particularly likely to occur if this drug is abused by injection (see Suboxone Withdrawal and Can You Shoot Up Suboxone?).

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using buprenorphine and naloxone or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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Buprenorphine and Naloxone Drug Information

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