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Drug Interactions With Budesonide Nasal Spray

Several medications may cause drug interactions with budesonide nasal spray, including certain antibiotics or antifungals and protease inhibitors. When these medicines are combined with the nasal spray, the level of budesonide in your blood can be increased and side effects may occur. Tell your healthcare provider about all medications you are taking to help prevent drug interactions with budesonide nasal spray.

Drug Interactions With Budesonide Nasal Spray: An Overview

Budesonide nasal spray (Rhinocort Aqua®) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with budesonide nasal spray include:
  • Certain antibiotics or antifungals, such as:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Telithromycin (Ketek®)
  • Protease inhibitors, such as:

More Information on Interactions With Budesonide Nasal Spray

The following sections explain in detail the potentially negative interactions that can occur when budesonide nasal spray is combined with any of the drugs listed above.
Certain Antibiotics and Antifungals
Some antibiotics and antifungals can increase the level of budesonide nasal spray in your blood, perhaps increasing your risk for side effects of budesonide nasal spray. In particular, too much budesonide nasal spray in your blood can suppress your body's ability to produce natural steroids, which can have serious consequences. This interaction is most likely to be a problem for people who take both antibiotics and antifungals on a long-term basis. Your healthcare provider may need to decrease your budesonide nasal spray dosage to prevent this interaction from occurring.
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