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Drug Interactions With Brentuximab Vedotin

Digoxin
Chemotherapy medicines, including brentuximab vedotin, may lower the amount of digoxin absorbed into the bloodstream, which could decrease its effectiveness. If you take digoxin in addition to brentuximab vedotin, your healthcare provider may check your digoxin blood levels, especially when you first start or stop using brentuximab vedotin, and adjust your dose if needed.
 
Echinacea
Echinacea can make brentuximab vedotin less effective. This is because echinacea is thought to stimulate the activity of the immune system, while brentuximab vedotin suppresses the activity of the immune system. Do not take echinacea during brentuximab vedotin treatment without your healthcare provider's approval.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine during brentuximab vedotin treatment, you may become infected with the virus or bacteria from the vaccine. Also, because brentuximab vedotin lowers the activity of the immune system, live vaccines may be less effective in people using this chemotherapy drug. Talk to your healthcare provider before receiving a vaccination while you are receiving brentuximab vedotin.
 
Sipuleucel-T
Sipuleucel-T may be less effective if taken with brentuximab vedotin. Talk to your healthcare provider about this possible interaction before using these medicines together.
 
Warfarin
Chemotherapy medicines, including brentuximab vedotin, have been reported to both increase and decrease the effects of warfarin. Therefore, your healthcare provider may need to monitor you more closely by checking your prothrombin time ("protime" or PT) and international normalized ratio (INR) when you first start or stop using brentuximab vedotin.
 
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