Brentuximab Vedotin Dosage
When prescribing brentuximab vedotin, your healthcare provider will take into consideration your weight and other factors. This medication comes as an injection that is given intravenously by your healthcare provider once every three weeks. To help prevent an infusion reaction, you may receive various other medications before receiving your dose of brentuximab vedotin.
An Introduction to Your Dosage of Brentuximab VedotinThe dose of brentuximab vedotin (Adcetris™) your healthcare provider recommends will vary, based on a number of factors, including:
- Your weight
- How well you tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Brentuximab Vedotin Dosing GuidelinesThe usual recommended dosage of brentuximab vedotin for the treatment of lymphoma is 1.8 mg per kg body weight (about 0.82 mg per lb) every three weeks. The dose for people who weigh over 220 lbs should be calculated based on a weight of 220 lbs, as this is the maximum recommended dosage. Treatment will generally continue until 16 doses have been given, as long as the medicine is working and is not causing serious side effects.
Your healthcare provider may recommend temporarily stopping the medicine if you experience certain side effects, such as peripheral neuropathy (numbness, tingling, or burning in the hands or feet from nerve damage) or low white blood cell counts. Once your side effects improve, you may be restarted on a lower dosage of 1.2 mg per kg body weight (about 0.54 mg per lb).
Some people may experience a potentially serious reaction, known as an infusion reaction, while receiving their brentuximab vedotin dosage. Therefore, you will be closely monitored during the infusion. Your healthcare provider may recommend you take other medicines before receiving your dose to help prevent an infusion reaction from occurring. This premedication may include products such as:
- Acetaminophen (Tylenol® and others)
- An antihistamine, such as diphenhydramine (Benadryl® and others)
- A corticosteroid, such as prednisolone (Orapred®, Pediapred®).