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What Is Bosentan Used For?

How Does Bosentan Work?

Bosentan is an endothelin receptor antagonist. Endothelins are proteins that have a variety of effects in the body, including on the heart, blood vessels, lungs, and kidneys. One of the things endothelins do is cause blood vessels to constrict (narrow).
 
People with PAH have higher-than-normal levels of endothelins in the body. Endothelin can bind to two receptors. Bosentan works by blocking both of those receptors, preventing endothelin from binding to them. This helps block the effects of the extra endothelin in people with PAH.
 

Can Children Use It?

Bosentan is not approved for use in children (usually defined as individuals younger than 18 years of age), as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using this medicine in a child.
 

Is It Safe for Older Adults to Use Bosentan?

There were not enough individuals over the age of 65 in clinical trials to determine if older individuals would respond to this drug any differently than younger age groups. Because older adults are more likely to have other health conditions and to take additional medications, bosentan may need to be used cautiously in older individuals. 
 

What About Off-Label Bosentan Uses?

On occasion, your healthcare provider may recommend this medicine for something other than the condition discussed in this article. This would be known as an "off-label" use. Some of the possible off-label uses for bosentan may include:
 
 

Bosentan Drug Information

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