When treating pulmonary arterial hypertension with bosentan, the dosage will be calculated based on your weight, other medications you are taking, and various other factors. This prescription medicine comes as tablets that are taken twice daily, in the morning and evening. Do not suddenly stop taking bosentan, as doing so can cause your symptoms to become worse.
An Introduction to Your Dosage of Bosentan
The dose of bosentan (Tracleer®) your healthcare provider recommends will vary, depending on a number of factors, including:
- Your weight
- Other medications you are taking
- Whether you develop certain side effects.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Recommended Bosentan Dosing Guidelines
The initial recommended bosentan dosage for treating pulmonary arterial hypertension is usually 62.5 mg twice a day for four weeks. After four weeks, the amount is normally increased to the recommended maintenance dose of 125 mg twice a day. However, it is recommended that people who weigh less than 40 kg (about 88 lbs) continue taking bosentan 62.5 mg twice a day as their maintenance dose.
For people who are taking a medication called ritonavir (Norvir®), the recommended initial dosage of bosentan is usually 62.5 mg once a day or 62.5 mg every other day. The actual amount used will be based on how well bosentan is tolerated.
Because this drug can cause liver damage, your healthcare provider will order regular blood tests to check your liver function. If the blood tests show early signs of liver damage, your healthcare provider may reduce your bosentan dosage, recommend a break in treatment, or permanently stop treatment. In clinical studies, doses above 125 mg twice a day did not increase the effectiveness of the medicine, but did increase the risk for liver damage.
If you will no longer need to take bosentan, your healthcare provider may recommend you gradually stop taking it. Stopping the medicine suddenly may cause your symptoms to become worse. Do not suddenly stop taking bosentan unless your healthcare provider tells you to do so.