Adults and children age 13 and older may use Berinert to help relieve pain and swelling that occurs during a sudden attack of hereditary angioedema (HAE). This prescription medicine is specifically approved for attacks that involve the face, abdomen (stomach area), or throat. It is given at the first sign of an attack to help relieve symptoms and prevent the attack from progressing.
Berinert® (C1 esterase inhibitor) is a prescription medication approved to treat the sudden attacks of swelling associated with hereditary angioedema (HAE). It belongs to a class of medicines known as C1 inhibitors. Another C1 inhibitor medication, Cinryze®, is approved to prevent HAE attacks from occurring in the first place.
HAE is a rare genetic disorder caused by the lack of a protein that controls inflammation and swelling. People with HAE can have intense episodes of swelling in various parts of their body. While the attacks can occur most anywhere in the body, they typically involve the hands, feet, face, genitals, upper airways, larynx (voice box), and abdomen (stomach area). Usually, only one area of the body is affected at a time.
HAE is an inherited condition, which means it is passed through families. However, it is important to note that in some cases there is no family history. Therefore, a person can have HAE even if no one in their family has previously been diagnosed with the condition.
Typically, HAE attacks begin in childhood and increase in severity beginning around puberty. The condition can affect each person differently. While some people may have weekly attacks, others may have attacks less than once a year. In addition, the severity of the attacks can vary from person to person.
In general, attacks are self-limiting, which means they resolve on their own. However, symptoms can last for days if not treated and can be life-threatening. For example, swelling of the throat can close off the airway and interfere with a person's ability to breathe.
Berinert is specifically approved to treat attacks that involve the face, abdomen (stomach area), or larynx (voice box or throat). It is given at the first sign of an attack to help reduce symptoms and prevent the attack from progressing. The medication can be administered by a healthcare provider, or, if a healthcare provider believes it is appropriate, may be self-administered. If you will be self-administering Berinert, your healthcare provider will teach you how to properly use it.