The recommended dosage of Berinert your healthcare provider prescribes is largely based on your weight. This medication comes as a powder that is dissolved in sterile water and injected into a vein. You or your healthcare provider may administer it. Do not inject Berinert if your attack has progressed to the point where you cannot mix and inject the medicine.
The dose of Berinert® (C1 esterase inhibitor) your healthcare provider recommends will vary, depending on your weight. As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
The usual recommended dosage of Berinert for the treatment of hereditary angioedema attacks is 20 international units (IU) per kg body weight (about 9.09 IU per lb) at the first signs of an attack. The minimum recommended dose is 20 IU.
Some considerations to keep in mind during treatment with Berinert include the following:
- This medication comes as a powder that is dissolved in Sterile Water for Injection to form a liquid. It is given as an injection into a vein (an intravenous, or IV, injection).
- Berinert injections may be given by your healthcare provider or, in some cases, it may be self-administered.
- You will need to receive approval and proper training by your healthcare provider to self-inject this medication.
- Berinert doses are given slowly, at a rate of about 4 mL per minute.
- If you self-administer Berinert to treat a laryngeal (voice box) attack, it is important to seek immediate medical attention afterward.
- If you self-administer to treat an abdominal (stomach) attack, let your healthcare provider know afterward so other possible medical causes of your symptoms can be excluded.
- You should not self-administer this medication if your attack has progressed to the point where you cannot completely prepare the dose or inject yourself with it. Instead, seek immediate medical attention.
- Once mixed for use, Berinert should be colorless and clear. Do not use the medication if it is discolored or contains particles.
- For the medication to work properly, it must be used as prescribed.
- If you are unsure about anything related to your dosage of Berinert, please talk with your healthcare provider, nurse, or pharmacist.