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Drug Interactions With Bedaquiline

More Detail on Drug Interactions With Bedaquiline

The following sections explain in detail the potentially negative interactions that can occur when bedaquiline is combined with any of the drugs listed above.
 
Alcohol
Drinking alcohol during bedaquiline treatment can increase your risk for liver damage. Do not drink alcohol while you are taking this medicine.
 
CYP 3A4 Inducer Medications
The liver breaks down bedaquiline using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining bedaquiline with one of these drugs may decrease the level of bedaquiline in your body, possibly making it less effective. In most cases, these medications should not be used together.
 
CYP 3A4 Inhibitor Medications
The liver breaks down bedaquiline using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining bedaquiline with one of these drugs may increase the level of bedaquiline in your body, potentially increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these drugs together. If he or she determines it is appropriate, you may need to be monitored more closely.
 
QT-Prolonging Medications
Bedaquiline can cause a potentially dangerous change in the heart rhythm known as QT prolongation. Taking it in combination with other medications that can cause QT prolongation may increase the risk for this problem. In many cases, it is safest to not use these medications together. If they must be used together, your healthcare provider may choose to closely monitor your heart rhythm with an electrocardiogram (ECG).
 

Final Thoughts

It is possible that not all bedaquiline drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 

Bedaquiline Drug Information

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