You should talk with your healthcare provider prior to taking this medication if you have:
- Ever had an abnormal heart rhythm (arrhythmia)
- A heart problem known as QT prolongation or congenital long QT syndrome
- Heart failure
- Hypothyroidism (an underactive thyroid)
- Been told you have low blood levels of calcium, magnesium, or potassium
- Had a recent heart attack
- Human immunodeficiency virus (HIV) infection
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Kidney disease, such as kidney failure (renal failure)
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Drink alcohol
- Are pregnant or thinking of becoming pregnant (see Sirturo and Pregnancy)
- Are breastfeeding (see Sirturo and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Bedaquiline to learn more, including information on who should not take the drug.)
Bedaquiline works by blocking an enzyme known as adenosine-5'-triphosphate (ATP) synthase. This enzyme is essential for creating energy that Mycobacterium tuberculosis (the bacteria that causes TB) needs to survive. By blocking this enzyme, bedaquiline prevents the bacteria from getting the energy it needs to survive and replicate.