When treating tuberculosis with bedaquiline, the recommended dosage is the same for everyone, regardless of age, weight, or other medications that are being taken. The tablets are taken once daily for 2 weeks, followed by three times a week for 22 more weeks. Bedaquiline must be used with at least three other tuberculosis medications.
There is only one standard recommended dose of bedaquiline (Sirturo™), regardless of your age, weight, or other medicines you are taking. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Bedaquiline is taken for a total of 24 weeks. The usual recommended dose for treating tuberculosis of the lungs over the 24-week treatment course is:
- 400 mg (four tablets) once a day during weeks 1 and 2 of treatment
- 200 mg (two tablets) three times a week during weeks 3 through 24. Doses during weeks 3 through 24 should be separated by at least 48 hours.
Bedaquiline must be used with at least three other tuberculosis medications. Your healthcare provider will determine which other drugs you should take. You may need to take these other products for longer than 24 weeks.
Some considerations to keep in mind during treatment with bedaquiline include the following:
- Bedaquiline comes in the form of a tablet. It is usually taken by mouth once a day for 2 weeks and then three times a week for 22 more weeks.
- This medication should be taken with food and water.
- Do not cut, crush, or chew the tablets. They must be swallowed whole.
- Bedaquiline is taken in combination with other tuberculosis medicines. Make sure you understand the instructions for taking these other products as well.
- You should not drink alcohol during bedaquiline treatment.
- For the medication to work properly, it must be taken as prescribed. It will not work to treat your infection if you do not take it, or take less than the full course. Also, missing doses or not taking the entire course of treatment may increase the risk that the bacteria will become resistant to bedaquiline or other tuberculosis medications.
- If you are unsure about anything related to your begaquiline dosage, please talk with your healthcare provider, nurse, or pharmacist.