What If I Overdose on This Medicine?At this time, it is not entirely clear what to expect from an overdose with basiliximab. An overdose is unlikely to occur, as a healthcare provider administers the medication in a healthcare setting. Nonetheless, it is important to seek medical attention if you believe you may have been given too much basiliximab.
(Click Simulect Overdose for more information.)
What If I Miss a Dose of Basiliximab?If you miss an appointment to receive your basiliximab dose, contact your healthcare provider right away to reschedule. It is important to try to keep your appointments to receive this medicine.
How Does It Work?Transplant rejection occurs when the immune system recognizes a transplanted organ as foreign and attacks it. T lymphocytes (a white blood cell type, sometimes simply called T cells) are an important part of the immune response involved in transplant rejection.
An antibody is a protein made by the immune system. Antibodies attach to substances in the body called antigens. Basiliximab is a manufactured antibody designed to bind to a specific antigen (known as CD25) found on the surface of T cells. Normally, interleukin-2 (a protein made by the body) binds to CD25 and stimulates T cells to mature and divide.
By binding to CD25, basiliximab blocks the action of interleukin-2, thus preventing T cells from multiplying. This decreases the number of T cells in the body and reduces the risk for transplant rejection.