Drug Interactions With Azelastine (Cont.)

Azelastine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when azelastine is combined with any of the drugs listed above.
 
Alcohol
People are typically advised to avoid alcohol while taking azelastine. Combining the two may increase the risk of drowsiness and decrease your alertness.
 
Barbiturates
Azelastine and barbiturates can both cause drowsiness, and taking them together increases this risk. Talk to your healthcare provider before taking these medications together.
 
Cimetidine
Cimetidine can increase the level of azelastine in your blood, potentially increasing your risk of side effects of azelastine. Your healthcare provider may recommend that you use one of the many cimetidine alternatives that do not interact with azelastine.
 
Narcotics or Opiates
Combining azelastine with narcotics or opiates can increase the risk of drowsiness and decrease your alertness. Talk with your healthcare provider before using azelastine with a narcotic or opiate.
 
Other Antihistamines
Using azelastine with another antihistamine is generally not recommended. Many antihistamines cause drowsiness, and taking more than one antihistamine at the same time usually increases this risk. Be aware that many non-prescription cold, cough, allergy, and flu products contain an antihistamine.
 

Final Thoughts on Drug Interactions With Azelastine

Not all drug interactions with azelastine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;