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Drug Interactions With Azelastine/Fluticasone Nasal Spray

More Information on Drug Interactions With Azelastine/Fluticasone Nasal Spray

The following sections explain in detail the potentially negative interactions that can occur when azelastine/fluticasone nasal spray is combined with any of the drugs listed above.
 
CYP 3A4 Inhibitors
The liver breaks down the fluticasone component of azelastine/fluticasone nasal spray using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining azelastine/fluticasone nasal spray with one of these drugs may increase the level of fluticasone in your bloodstream, increasing your risk for side effects. This is an important and potentially serious interaction, even for fluticasone in the form of a nasal spray. Some CYP 3A4 inhibitors have a greater effect than others. Check with your healthcare provider before combining azelastine/fluticasone nasal spray with one of these drugs.
 
The prescribing information specifically warns against combining azelastine/fluticasone nasal spray with ritonavir, which is a particularly strong CYP 3A4 inhibitor, stating that this combination is not recommended.
 
Medications That Cause Drowsiness
Azelastine (the antihistamine in azelastine/fluticasone nasal spray) can sometimes cause drowsiness. Thus, combining azelastine/fluticasone nasal spray with other medications that can cause drowsiness may lead to additive effects, perhaps decreasing mental alertness and interfering with your ability to operate a vehicle or heavy machinery.
 

Final Thoughts

It is possible that not all azelastine/fluticasone nasal spray drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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Azelastine/Fluticasone Nasal Spray Information

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