Azelastine/Fluticasone Nasal Spray
Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to using this medication if you have:
- Recently had nasal surgery
- Sores or injury to the inside of your nose
- Not had chickenpox or the measles (or have not been vaccinated against them)
- Tuberculosis, herpes, or any other infections
- Glaucoma or cataracts
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Azelastine/Fluticasone Nasal Spray to learn more, including information on who should not use this product.)
How Does It Work?Allergies occur as the result of the immune system's reaction to normally harmless substances that do not bother most people. This reaction is known as inflammation, and involves several different types of cells and several different chemicals in the body.
Azelastine/fluticasone nasal spray contains two separate medications: fluticasone and azelastine. Fluticasone is a corticosteroid, or simply "steroid" for short. Steroids can have many different effects in the body, including anti-inflammatory effects. Steroids decrease inflammation by limiting the body's ability to produce an immune system reaction. They can be quite effective for treating conditions such as allergies.
However, long-term use of steroids can cause bothersome and sometimes serious side effects, and this limits the usefulness of many steroids. Because this medicine is a nasal spray, its effects are generally limited to the nose. This helps prevent many of the long-term steroidal side effects.
The other active ingredient (azelastine) is an antihistamine. Allergy symptoms are partly caused by the release of histamine from certain cells, known as mast cells. Azelastine is an antihistamine that acts in at least two different ways. It helps prevent the release of histamine from mast cells, and if any histamine is released, azelastine also prevents it from binding to histamine receptors. Because histamine is responsible for many of the symptoms of allergies, blocking it can be quite helpful.