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Side Effects of Atovaquone/Proguanil

Although most people are able to take atovaquone/proguanil without any problems, side effects are possible. For example, nausea, muscle pain, and headache are some of the most commonly reported side effects of the drug. Serious problems -- though not as common -- can also occur. These include seizures, red spots on the skin, and allergic reactions, such as hives or difficulty breathing.

An Introduction to Side Effects of Atovaquone/Proguanil

Just like any medicine, atovaquone/proguanil (Malarone®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible atovaquone/proguanil side effects. Your healthcare provider can discuss a more complete list with you.)

Serious Atovaquone/Proguanil Side Effects

Some side effects of atovaquone/proguanil are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Seizures
  • Seeing, hearing, or feeling things that are not there (hallucinations)
  • Increased sensitivity to the sun, or easy burning in the sun
  • Inflammation, redness, swelling, or bleeding of the mouth, including the cheeks, tongue, gums, and lips
  • A skin rash that is red, blistering, or peeling
  • Red spots on your skin
  • Signs of anemia or other blood cell problems, including:
    • Fatigue or extreme weakness or tiredness
    • Unusual bruising or bleeding
    • High fever, aches, and pains, which may be signs of an infection
  • Signs of liver problems or liver failure, including:
    • Dark urine
    • Loss of appetite
    • Pain in the upper part of the stomach
    • Yellowing of the whites of the eyes or skin (jaundice)
    • General feelings of discomfort
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.

Atovaquone/Proguanil Drug Information

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