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Drug Interactions With Atovaquone/Proguanil

More Details on Drug Interactions With Atovaquone/Proguanil

The following sections explain in detail the potentially negative interactions that can occur when atovaquone/proguanil is combined with any of the drugs listed above.
 
Artemether-Lumefantrine
Taking atovaquone/proguanil with artemether-lumefantrine, another antimalarial medication, may make the side effects of either drug more pronounced. It should be noted that sometimes antimalarial medications are used together to treat malaria; however, this should only be done under the supervision of a healthcare provider.
 
Dapsone
Taking atovaquone/proguanil with dapsone may increase your risk of serious blood reactions. This risk is highest in people who have certain blood conditions, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, methemoglobin reductase deficiency, or hemoglobin M.
 
If you have one of these conditions, you should discuss this drug interactions with your healthcare provider. If you must take these medications together, your healthcare provider may choose to closely monitor you for blood reactions.
 
Etoposide
Atovaquone/proguanil may increase the levels of etoposide in your body, increasing your risk for adverse reactions. Your healthcare provider may choose to separate your doses of these medications by one to two days to help reduce the risk of this reaction.
 
Indinavir
Atovaquone/proguanil may reduce the levels of indinavir in your body, potentially making it less effective. If you take these medications together, your healthcare provider may choose to monitor you more closely to make sure you are responding to indinavir.
 
Metoclopramide
Metoclopramide may reduce the levels of atovaquone/proguanil in your body, potentially making it less effective. Talk to your healthcare provider about the best medication to use if you need something for nausea and vomiting while taking atovaquone/proguanil. Metoclopramide should only be used if no other options are available.

Atovaquone/Proguanil Drug Information

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