Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to taking this medication if you have:
- Kidney disease, such as kidney failure (renal failure)
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Recent vomiting or diarrhea
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Malarone and Pregnancy)
- Breastfeeding (see Malarone and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Atovaquone/Proguanil to learn more, including information on who should not take the drug.)
How Does Atovaquone/Proguanil Work?Atovaquone/proguanil belongs to the antimalarial class of medications. Malaria is a blood infection caused by tiny parasites called Plasmodium. Plasmodium are usually introduced into the bloodstream by the bite of an infected mosquito. Once in the bloodstream, these parasites start to reproduce.
Atovaquone/proguanil prevents Plasmodium parasites from copying nucleic acid, an essential step in their reproduction. The two components of atovaquone/proguanil do this in slightly different ways, allowing them to work well in combination to prevent Plasmodium parasites from reproducing in the bloodstream.